Tuesday, May 21, 2013

U.S. Army Awards Cubic $21M Foreign Military Sales Training ...

Cubic Corporation (NYSE: CUB), announced today it was awarded a $21 million foreign military sales contract for its Engagement Skills Trainer 2000 (EST 2000) Plus, virtual small arms training system. The U.S. Army's Program Executive Office for Simulation, Training and Instrumentation (PEO STRI) awarded the contract to Cubic in support of a foreign customer. The order includes systems, weapons, and in-country support with a key subcontractor.

EST 2000, built by the Cubic Simulation Systems division based in Orlando, Florida, uses digital video projectors, high-definition screens, game-based computer graphics and ballistically accurate weapons for marksmanship, collective and escalation of force training.

"This contract emphasizes Cubic's commitment to our allies around the world. We understand the importance of virtual and immersive training systems for mission-specific tasks. Our EST 2000 systems set the highest standard for small arms engagement skills training in the world," said Terry Kohl, Senior Vice President and General Manager of Cubic's Simulations Systems Division.

About Cubic Corporation

Cubic Corporation is the parent company of three major business segments: Defense Systems, Mission Support Services and Transportation Systems. Cubic Defense Systems is a leading provider of realistic combat training systems, cyber technologies, asset tracking solutions, and defense electronics. Mission Support Services is a leading provider of training, operations, maintenance, technical and other support services to the U.S. and allied nations. Cubic Transportation Systems is a leading provider of automated fare collection systems and services for public transit authorities. For more information about Cubic, see the company's web site at http://www.cubic.com.

This article was originally distributed on PRWeb. For the original version including any supplementary images or video, visit http://www.prweb.com/releases/2013/5/prweb10750743.htm

Source: http://www.benzinga.com/news/13/05/3604907/u-s-army-awards-cubic-21m-foreign-military-sales-training-contract

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ESPN cutting workforce, 'smartly managing costs'

NEW YORK (AP) ? ESPN says that it is cutting its workforce.

The sports media giant said in a statement Tuesday: "We are implementing changes across the company to enhance our continued growth while smartly managing costs." The company would not say how many jobs are being eliminated, but they include unfilled positions.

ESPN has about 7,000 employees worldwide, with about 4,000 at its headquarters in Bristol, Conn. The vast majority work behind the scenes.

This is the latest in a series of recent job cuts at several Disney divisions. ESPN specifically has seen costs increase with skyrocketing prices for the broadcasting rights to live sports.

Source: http://news.yahoo.com/espn-cutting-workforce-smartly-managing-costs-165708821.html

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U of M researchers develop model for better testing, targeting of MPNST

U of M researchers develop model for better testing, targeting of MPNST [ Back to EurekAlert! ] Public release date: 20-May-2013
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Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center

MINNEAPOLIS/ST. PAUL (MAY 20, 2013) University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors (MPNST) that allow them to discover new genes and gene pathways driving this type of cancer.

The research was published this week in the journal Nature Genetics.

Utilizing the Sleeping Beauty transposon method, researchers in the lab of David Largaespada, Ph.D., professor in the Medical School and College of Biological Sciences, were able to use an unbiased approach to generate mouse models of MPNST development that lead to the identification of genes related to this tumor's development.

MPNST is a genetically diverse, aggressive form of sarcoma impacting connective tissue surrounding nerves that occurs sporadically or in association with Neurofibromatosis Type 1 (NF1) syndrome. The exact cause of MPNST is not known, but symptoms include swelling in the arms and legs, soreness and stiffness at the site of the tumor. MPNSTs are the most common malignancy in adults with NF1 syndrome and leading cause of NF1-related mortality.

Due to the invasive nature and high incidence of metastasis of MPNSTs, surgical resection, radiotherapy and chemotherapeutic treatments have proven to be ineffective for long-term treatment, resulting in 5-year survival rates of less than 25 percent with metastatic disease.

One of the most surprising findings in this research showed the gene FOXR2 is intrinsically linked to the growth of MPNSTs. This gene has not been heavily studied as researchers had not identified a clear function of this gene.

"By using an unbiased approach, it helped us identify FOXR2 as an important gene in MPNST development and develop experiments to pinpoint the role FOXR2 plays in maintaining the aggressive nature of these tumors," said Eric Rahrmann, Ph.D., the paper's lead author and a postdoctoral fellow in the Largaespada lab. "When we turn off FOXR2, the growth ability of these MPNSTs drastically decreases."

Other findings showed interesting evidence of pathways that could be viable targets for therapeutics. The activation of the Wnt signaling pathway was shown to drive MPNSTs. This pathway has been highly implicated in colon cancer but not previously linked to MPNSTs.

Researchers also found many of the MPNSTs have dual loss of the genes called NF1 and PTEN. This pairing of lost genes causes MPNST formation. Both of these genes have previously been shown as pathways related to MPNSTs but it wasn't clear the extent to which they work together.

Now, researchers are applying these findings to the testing of therapeutics currently on the market for other drugs. This research is continuing both in the mouse model and within primary tumor settings of human cell lines.

"We want to know if these drugs, which are not currently directed at MPNSTs, could be repurposed to provide alternate therapies for patients," said Largaespada.

Researchers are also looking into more direct ways to target tumors through the Wnt pathway and paired NF1 and PTEN pathways, utilizing mouse models and human cell lines in the lab setting.

###

Funding for this project came from the National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) grant P50 N5057531, the Margaret Harvey Schering Trust and the Zachary Neurofibromatosis Research Fund, and the Jacqueline Dunlap Neurofibromatosis Research Fund. Additional resources for contributing authors includes the Children's Tumor Foundation Young Investigator's Award 2011-01-018.

Masonic Cancer Center, University of Minnesota is part of the University's Academic Health Center. It is designated by the National Cancer Institute as a Comprehensive Cancer Center. For more information about the Masonic Cancer Center, visit http://www.cancer.umn.edu or call 612-624-2620.

The University of Minnesota Medical School, with its two campuses in the Twin Cities and Duluth, is a leading educator of the next generation of physicians. Our graduates and the school's 3,800 faculty physicians and scientists advance patient care, discover biomedical research breakthroughs with more than $180 million in sponsored research annually, and enhance health through world-class patient care for the state of Minnesota and beyond. Visit http://www.med.umn.edu to learn more.

For more information on brain tumors please consider attending the Second Minnesota Neuro-Oncology Symposium in Minneapolis on September 26-27, 2013. More information and registration can be found at braintumorprogram.umn.edu.


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U of M researchers develop model for better testing, targeting of MPNST [ Back to EurekAlert! ] Public release date: 20-May-2013
[ | E-mail | Share Share ]

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center

MINNEAPOLIS/ST. PAUL (MAY 20, 2013) University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors (MPNST) that allow them to discover new genes and gene pathways driving this type of cancer.

The research was published this week in the journal Nature Genetics.

Utilizing the Sleeping Beauty transposon method, researchers in the lab of David Largaespada, Ph.D., professor in the Medical School and College of Biological Sciences, were able to use an unbiased approach to generate mouse models of MPNST development that lead to the identification of genes related to this tumor's development.

MPNST is a genetically diverse, aggressive form of sarcoma impacting connective tissue surrounding nerves that occurs sporadically or in association with Neurofibromatosis Type 1 (NF1) syndrome. The exact cause of MPNST is not known, but symptoms include swelling in the arms and legs, soreness and stiffness at the site of the tumor. MPNSTs are the most common malignancy in adults with NF1 syndrome and leading cause of NF1-related mortality.

Due to the invasive nature and high incidence of metastasis of MPNSTs, surgical resection, radiotherapy and chemotherapeutic treatments have proven to be ineffective for long-term treatment, resulting in 5-year survival rates of less than 25 percent with metastatic disease.

One of the most surprising findings in this research showed the gene FOXR2 is intrinsically linked to the growth of MPNSTs. This gene has not been heavily studied as researchers had not identified a clear function of this gene.

"By using an unbiased approach, it helped us identify FOXR2 as an important gene in MPNST development and develop experiments to pinpoint the role FOXR2 plays in maintaining the aggressive nature of these tumors," said Eric Rahrmann, Ph.D., the paper's lead author and a postdoctoral fellow in the Largaespada lab. "When we turn off FOXR2, the growth ability of these MPNSTs drastically decreases."

Other findings showed interesting evidence of pathways that could be viable targets for therapeutics. The activation of the Wnt signaling pathway was shown to drive MPNSTs. This pathway has been highly implicated in colon cancer but not previously linked to MPNSTs.

Researchers also found many of the MPNSTs have dual loss of the genes called NF1 and PTEN. This pairing of lost genes causes MPNST formation. Both of these genes have previously been shown as pathways related to MPNSTs but it wasn't clear the extent to which they work together.

Now, researchers are applying these findings to the testing of therapeutics currently on the market for other drugs. This research is continuing both in the mouse model and within primary tumor settings of human cell lines.

"We want to know if these drugs, which are not currently directed at MPNSTs, could be repurposed to provide alternate therapies for patients," said Largaespada.

Researchers are also looking into more direct ways to target tumors through the Wnt pathway and paired NF1 and PTEN pathways, utilizing mouse models and human cell lines in the lab setting.

###

Funding for this project came from the National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) grant P50 N5057531, the Margaret Harvey Schering Trust and the Zachary Neurofibromatosis Research Fund, and the Jacqueline Dunlap Neurofibromatosis Research Fund. Additional resources for contributing authors includes the Children's Tumor Foundation Young Investigator's Award 2011-01-018.

Masonic Cancer Center, University of Minnesota is part of the University's Academic Health Center. It is designated by the National Cancer Institute as a Comprehensive Cancer Center. For more information about the Masonic Cancer Center, visit http://www.cancer.umn.edu or call 612-624-2620.

The University of Minnesota Medical School, with its two campuses in the Twin Cities and Duluth, is a leading educator of the next generation of physicians. Our graduates and the school's 3,800 faculty physicians and scientists advance patient care, discover biomedical research breakthroughs with more than $180 million in sponsored research annually, and enhance health through world-class patient care for the state of Minnesota and beyond. Visit http://www.med.umn.edu to learn more.

For more information on brain tumors please consider attending the Second Minnesota Neuro-Oncology Symposium in Minneapolis on September 26-27, 2013. More information and registration can be found at braintumorprogram.umn.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/uoma-uom052013.php

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The first Jolla phone: 4.5-inch display, Android app compliant, 399 euros

The first Jolla phone 45inch display, Android app compliant, 399 euros

Jolla's heavily teased launch day in Finland has already spilled some major news: pricing and specs for the first Sailfish OS handset. The phone seems to be called "The Other Half" -- or at least that's the working title for now -- and judging from Jolla's Facebook page it consists of a colorful plastic case, available in various shades including orange or green, which hooks onto the main chassis containing a 4.5-inch display (of unknown resolution), dual-core processor, microSD expansion with 16GB onboard, a "4G" modem, user replaceable battery and an 8MP rear camera. The chassis recognizes which case is attached and adapts the visual theme of the OS to match, creating "your other half, exactly as you want it to be."

Perhaps more usefully, the Sailfish operating system will also be Android app compliant out of the box, and we're currently on the ground in Helsinki trying to discover exactly how developers and users will be able to put that feature to work (while also chasing down the rest of the specs). Meanwhile, there's an emphatic video message from Jolla co-founder Marc Dillon after the break, seeking the world's assistance in taking the heritage of MeeGo into a new era.

Update: We now hear that the phone will simply be called the "Jolla."

Update #2: Jolla has just clarified that 4G means LTE. The display resolution has been vaguely described as "HD," which to our minds suggests 720p. Furthermore, it sounds like the way the "other half" interfaces with the main body of the device allows for much deeper functionality beyond just personalization. We've just added our own video tour with more information.

[Thanks, Toni]

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Comments

Source: Jolla

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/8x-kqFi1q0M/

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Obama to speak on legality of drone program (The Arizona Republic)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/306836830?client_source=feed&format=rss

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Bernanke sees more growth over the fifty years from innovation like ...

Bernanke told a college graduating class Saturday that the long-range practical consequences of innovations such as faster computers and the Internet are hard to predict. But he said inventors have only scratched the surface of the commercial applications that can be obtained in such fields as medicine (personal genomics, life extension) and clean energy. He also indicated that having two to four times as many engineers and scientists with China and India and other countries contributing to technological innovation will drive development forward at a faster pace. He was specifically addressing the debate around technological stagnation put forward by Tyler Cowan and Peter Thiel.

The entire text of the speech is at the Federal reserve website.

My emphasis today will be on prospects for the long run. In particular, I will be looking beyond the very real challenges of economic recovery that we face today--challenges that I have every confidence we will overcome--to speak, for a change, about economic growth as measured in decades, not months or quarters

Many factors affect the development of the economy, notably among them a nation's economic and political institutions, but over long periods probably the most important factor is the pace of scientific and technological progress. Between the days of the Roman Empire and when the Industrial Revolution took hold in Europe, the standard of living of the average person throughout most of the world changed little from generation to generation. For centuries, many, if not most, people produced much of what they and their families consumed and never traveled far from where they were born. By the mid-1700s, however, growing scientific and technical knowledge was beginning to find commercial uses. Since then, according to standard accounts, the world has experienced at least three major waves of technological innovation and its application. The first wave drove the growth of the early industrial era, which lasted from the mid-1700s to the mid-1800s. This period saw the invention of steam engines, cotton-spinning machines, and railroads. These innovations, by introducing mechanization, specialization, and mass production, fundamentally changed how and where goods were produced and, in the process, greatly increased the productivity of workers and reduced the cost of basic consumer goods. The second extended wave of invention coincided with the modern industrial era, which lasted from the mid-1800s well into the years after World War II. This era featured multiple innovations that radically changed everyday life, such as indoor plumbing, the harnessing of electricity for use in homes and factories, the internal combustion engine, antibiotics, powered flight, telephones, radio, television, and many more. The third era, whose roots go back at least to the 1940s but which began to enter the popular consciousness in the 1970s and 1980s, is defined by the information technology (IT) revolution, as well as fields like biotechnology that improvements in computing helped make possible. Of course, the IT revolution is still going on and shaping our world today.

Now here's a question--in fact, a key question, I imagine, from your perspective. What does the future hold for the working lives of today's graduates? The economic implications of the first two waves of innovation, from the steam engine to the Boeing 747, were enormous. These waves vastly expanded the range of available products and the efficiency with which they could be produced. Indeed, according to the best available data, output per person in the United States increased by approximately 30 times between 1700 and 1970 or so, growth that has resulted in multiple transformations of our economy and society. History suggests that economic prospects during the coming decades depend on whether the most recent revolution, the IT revolution, has economic effects of similar scale and scope as the previous two. But will it?

I must report that not everyone thinks so. Indeed, some knowledgeable observers have recently made the case that the IT revolution, as important as it surely is, likely will not generate the transformative economic effects that flowed from the earlier technological revolutions. As a result, these observers argue, economic growth and change in coming decades likely will be noticeably slower than the pace to which Americans have become accustomed. Such an outcome would have important social and political--as well as economic--consequences for our country and the world.

This provocative assessment of our economic future has attracted plenty of attention among economists and others as well. Does it make sense? Here's one way to think more concretely about the argument that the pessimists are making: Fifty years ago, in 1963, I was a nine-year-old growing up in a middle-class home in a small town in South Carolina. As a way of getting a handle on the recent pace of economic change, it's interesting to ask how my family's everyday life back then differed from that of a typical family today. Well, if I think about it, I could quickly come up with the Internet, cellphones, and microwave ovens as important conveniences that most of your families have today that my family lacked 50 years ago. Health care has improved some since I was young; indeed, life expectancy at birth in the United States has risen from 70 years in 1963 to 78 years today, although some of this improvement is probably due to better nutrition and generally higher levels of income rather than advances in medicine alone. Nevertheless, though my memory may be selective, it doesn't seem to me that the differences in daily life between then and now are all that large. Heating, air conditioning, cooking, and sanitation in my childhood were not all that different from today. We had a dishwasher, a washing machine, and a dryer. My family owned a comfortable car with air conditioning and a radio, and the experience of commercial flight was much like today but without the long security lines. For entertainment, we did not have the Internet or video games, as I mentioned, but we had plenty of books, radio, musical recordings, and a color TV (although, I must acknowledge, the colors were garish and there were many fewer channels to choose from).

The comparison of the world of 1963 with that of today suggests quite substantial but perhaps not transformative economic change since then. But now let's run this thought experiment back another 50 years, to 1913 (the year the Federal Reserve was created by the Congress, by the way), and compare how my grandparents and your great-grandparents lived with how my family lived in 1963. Life in 1913 was simply much harder for most Americans than it would be later in the century. Many people worked long hours at dangerous, dirty, and exhausting jobs--up to 60 hours per week in manufacturing, for example, and even more in agriculture. Housework involved a great deal of drudgery; refrigerators, freezers, vacuum cleaners, electric stoves, and washing machines were not in general use, which should not be terribly surprising since most urban households, and virtually all rural households, were not yet wired for electricity. In the entertainment sphere, Americans did not yet have access to commercial radio broadcasts and movies would be silent for another decade and a half. Some people had telephones, but no long-distance service was available. In transportation, in 1913 Henry Ford was just beginning the mass production of the Model T automobile, railroads were powered by steam, and regular commercial air travel was quite a few years away. Importantly, life expectancy at birth in 1913 was only 53 years, reflecting not only the state of medical science at the time--infection-fighting antibiotics and vaccines for many deadly diseases would not be developed for several more decades--but also deficiencies in sanitation and nutrition. This was quite a different world than the one in which I grew up in 1963 or in which we live today.

The purpose of these comparisons is to make concrete the argument made by some economists, that the economic and technological transformation of the past 50 years, while significant, does not match the changes of the 50 years--or, for that matter, the 100 years--before that. Extrapolating to the future, the conclusion some have drawn is that the sustainable pace of economic growth and change and the associated improvement in living standards will likely slow further, as our most recent technological revolution, in computers and IT, will not transform our lives as dramatically as previous revolutions have.

Well, that's sort of depressing. Is it true, then, as baseball player Yogi Berra said, that the future ain't what it used to be? Nobody really knows; as Berra also astutely observed, it's tough to make predictions, especially about the future. But there are some good arguments on the other side of this debate.

First, innovation, almost by definition, involves ideas that no one has yet had, which means that forecasts of future technological change can be, and often are, wildly wrong. A safe prediction, I think, is that human innovation and creativity will continue; it is part of our very nature. Another prediction, just as safe, is that people will nevertheless continue to forecast the end of innovation. The famous British economist John Maynard Keynes observed as much in the midst of the Great Depression more than 80 years ago. He wrote then, "We are suffering just now from a bad attack of economic pessimism. It is common to hear people say that the epoch of enormous economic progress which characterised the 19th century is over; that the rapid improvement in the standard of life is now going to slow down."3 Sound familiar? By the way, Keynes argued at that time that such a view was shortsighted and, in characterizing what he called "the economic possibilities for our grandchildren," he predicted that income per person, adjusted for inflation, could rise as much as four to eight times by 2030. His guess looks pretty good; income per person in the United States today is roughly six times what it was in 1930.

Second, not only are scientific and technical innovation themselves inherently hard to predict, so are the long-run practical consequences of innovation for our economy and our daily lives. Indeed, some would say that we are still in the early days of the IT revolution; after all, computing speeds and memory have increased many times over in the 30-plus years since the first personal computers came on the market, and fields like biotechnology are also advancing rapidly. Moreover, even as the basic technologies improve, the commercial applications of these technologies have arguably thus far only scratched the surface. Consider, for example, the potential for IT and biotechnology to improve health care, one of the largest and most important sectors of our economy. A strong case can be made that the modernization of health-care IT systems would lead to better-coordinated, more effective, and less costly patient care than we have today, including greater responsiveness of medical practice to the latest research findings.4 Robots, lasers, and other advanced technologies are improving surgical outcomes, and artificial intelligence systems are being used to improve diagnoses and chart courses of treatment. Perhaps even more revolutionary is the trend toward so-called personalized medicine, which would tailor medical treatments for each patient based on information drawn from that individual's genetic code. Taken together, such advances could lead to another jump in life expectancy and improved health at older ages/

Other promising areas for the application of new technologies include the development of cleaner energy--for example, the harnessing of wind, wave, and solar power and the development of electric and hybrid vehicles--as well as potential further advances in communications and robotics. I'm sure that I can't imagine all of the possibilities, but historians of science have commented on our collective tendency to overestimate the short-term effects of new technologies while underestimating their longer-term potential.

Finally, pessimists may be paying too little attention to the strength of the underlying economic and social forces that generate innovation in the modern world. Invention was once the province of the isolated scientist or tinkerer. The transmission of new ideas and the adaptation of the best new insights to commercial uses were slow and erratic. But all of that is changing radically. We live on a planet that is becoming richer and more populous, and in which not only the most advanced economies but also large emerging market nations like China and India increasingly see their economic futures as tied to technological innovation. In that context, the number of trained scientists and engineers is increasing rapidly, as are the resources for research being provided by universities, governments, and the private sector. Moreover, because of the Internet and other advances in communications, collaboration and the exchange of ideas take place at high speed and with little regard for geographic distance. For example, research papers are now disseminated and critiqued almost instantaneously rather than after publication in a journal several years after they are written. And, importantly, as trade and globalization increase the size of the potential market for new products, the possible economic rewards for being first with an innovative product or process are growing rapidly.6 In short, both humanity's capacity to innovate and the incentives to innovate are greater today than at any other time in history.

Well, what does all this have to do with creativity and critical thinking, which is where I started? The history of technological innovation and economic development teaches us that change is the only constant. During your working lives, you will have to reinvent yourselves many times. Success and satisfaction will not come from mastering a fixed body of knowledge but from constant adaptation and creativity in a rapidly changing world. Engaging with and applying new technologies will be a crucial part of that adaptation. Your work here at Simon's Rock, and the intellectual skills, creativity, and imagination that that work has fostered, are the best possible preparation for these challenges. And while I have emphasized technological and scientific advances today, it is important to remember that the arts and humanities facilitate new and creative thinking as well, while helping us to draw meaning that goes beyond the purely material aspects of our lives. I wish you the best in facing the difficult but exciting challenges that lie ahead. Congratulations.

If you liked this article, please give it a quick review on ycombinator or StumbleUpon. Thanks

Source: http://nextbigfuture.com/2013/05/bernanke-sees-more-growth-over-fifty.html

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Monday, May 20, 2013

Immune protein could stop diabetes in its tracks, discovery suggests

May 20, 2013 ? Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed.

The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis.

Professor Len Harrison, Dr Esther Bandala-Sanchez and Dr Yuxia Zhang led the research team from the Walter and Eliza Hall Institute's Molecular Medicine division that identified the immune protein CD52 as responsible for suppressing the immune response, and its potential for protecting against autoimmune diseases. The research was published today in the journal Nature Immunology.

So-called autoimmune diseases develop when the immune system goes awry and attacks the body's own tissues. Professor Harrison said CD52 held great promise as a therapeutic agent for preventing and treating autoimmune diseases such as type 1 diabetes.

"Immune suppression by CD52 is a previously undiscovered mechanism that the body uses to regulate itself, and protect itself against excessive or damaging immune responses," Professor Harrison said. "We are excited about the prospect of developing this discovery to clinical trials as soon as possible, to see if CD52 can be used to prevent and treat type 1 diabetes and other autoimmune diseases. This has already elicited interest from pharmaceutical companies."

Type 1 diabetes is an autoimmune disease that develops when immune cells attack and destroy insulin-producing beta cells in the pancreas. Approximately 120,000 Australians have type 1 diabetes and incidence has doubled in the last 20 years. "Type 1 diabetes is a life-long disease," Professor Harrison said. "It typically develops in children and teenagers, and it really makes life incredibly difficult for them and their families. It also causes significant long-term complications involving the eyes, kidneys and blood vessel damage, and at great cost to the community."

Professor Harrison said that T cells that have or release high levels of CD52 are necessary to maintain normal balance in the immune system. "In a preclinical model of type 1 diabetes, we showed that removal of CD52-producing immune cells led to rapid development of diabetes. We think that cells that release CD52 are essential to prevent the development of autoiummune disease, and that CD52 has great potential as a therapeutic agent," he said.

CD52 appears to play a dominant role in controlling or suppressing immune activity in the early stages of the immune response, Professor Harrison said. "We identified a specialised population of immune cells (T cells) that carry high levels of CD52, which they release to dampen the activity of other T cells and prevent uncontrolled immune responses," Professor Harrison said. "The cells act as an early 'braking' mechanism."

Professor Harrison said his goal is to prevent and ultimately cure type 1 diabetes. "In animal models we can prevent and cure type 1 diabetes," Professor Harrison said. "I am hopeful that these results will be translatable into humans, hopefully in the not-too-distant future."

This research was supported by the National Health and Medical Research Council of Australia and the Victorian Government.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/iaYlvvEkaNs/130520104932.htm

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Tunisia security blocks salafi conference

A Tunisian security officer stands guard in the city of Kairouan where ultraconservative Islamic group, Ansar al-Shariah's, annual conference was supposed to be held, Sunday May 19, 2013. A massive Tunisian security presence has surrounded the country?s main religious center of Kairouan and prevented hardline Muslims from holding their annual gathering. Some 11,000 police surrounded the city this weekend and patrolled inside to prevent the conference from taking place because ?of the threat it represented to security and public order.? (AP Photo/ Amine Landoulsi)

A Tunisian security officer stands guard in the city of Kairouan where ultraconservative Islamic group, Ansar al-Shariah's, annual conference was supposed to be held, Sunday May 19, 2013. A massive Tunisian security presence has surrounded the country?s main religious center of Kairouan and prevented hardline Muslims from holding their annual gathering. Some 11,000 police surrounded the city this weekend and patrolled inside to prevent the conference from taking place because ?of the threat it represented to security and public order.? (AP Photo/ Amine Landoulsi)

A Tunisian security officer stands guard in the city of Kairouan where ultraconservative Islamic group, Ansar al-Shariah's, annual conference was supposed to be held, Sunday May 19, 2013. A massive Tunisian security presence has surrounded the country?s main religious center of Kairouan and prevented hardline Muslims from holding their annual gathering. Some 11,000 police surrounded the city this weekend and patrolled inside to prevent the conference from taking place because ?of the threat it represented to security and public order.? (AP Photo/ Amine Landoulsi)

Tunisian security officers stand guard, in the city of Kairouan, where ultraconservative Islamic group Ansar al-Shariah's annual conference was supposed to be held, Sunday May 19, 2013. A massive Tunisian security presence has surrounded the country?s main religious center of Kairouan and prevented hardline Muslims from holding their annual gathering. Some 11,000 police surrounded the city this weekend and patrolled inside to prevent the conference from taking place because ?of the threat it represented to security and public order.? (AP Photo/ Amine Landoulsi)

Tunisian security officers check vehicles in the city of Kairouan where ultraconservative Islamic group, Ansar al-Shariah's, annual conference was supposed to be held, Sunday May 19, 2013. A massive Tunisian security presence has surrounded the country?s main religious center of Kairouan and prevented hardline Muslims from holding their annual gathering. Some 11,000 police surrounded the city this weekend and patrolled inside to prevent the conference from taking place because ?of the threat it represented to security and public order.? (AP Photo/ Amine Landoulsi)

Tunisian security officers stand guard in the city of Kairouan where ultraconservative Islamic group, Ansar al-Shariah's, annual conference was supposed to be held, Sunday May 19, 2013. A massive Tunisian security presence has surrounded the country?s main religious center of Kairouan and prevented hardline Muslims from holding their annual gathering. Some 11,000 police surrounded the city this weekend and patrolled inside to prevent the conference from taking place because ?of the threat it represented to security and public order.? (AP Photo/ Amine Landoulsi)

(AP) ? Massive numbers of Tunisian police and army surrounded Tunisia's religious center of Kairouan to prevent a conference by a radical Islamist movement that has been implicated in attacks around the country.

Security check points on the roads and patrols inside the city by some 11,000 police and soldiers prevented the ultraconservative Muslim group Ansar al-Shariah from holding its annual conference after authorities declared it a threat "to security and public order."

Police did briefly scuffle with stone throwing young men in downtown and fired tear gas to disperse them.

The leader of Ansar al-Shariah, Seifallah Ben Hassine is wanted for his involvement in a mob attack on the U.S. embassy in September and his followers have been accused of attacking art galleries, police stations and cinemas.

The robust response to the conference by security forces is unprecedented since the 2011 overthrow of President Zine El-Abidine Ben Ali, who presided over a strong police state.

The government, led by the moderate Islamist Ennahda Party, has long been accused by the opposition of being lax with attacks by ultraconservative Muslims, called salafis, on what they deem to be impious in the country.

Ansar al-Shariah's combative rhetoric, however, appears to have united the country against it. In a national dialogue conference involving unions, civil society and political parties Thursday, Ansar al-Shariah was widely condemned.

The spokesman of Ansar al-Shariah, Seifeddine Rais, was detained by authorities Sunday morning and an attempt by members to hold a rally in a lower income Tunisian suburb was also dispersed by tear gas.

Rais on Thursday said that the authorities would bear responsibility for any blood spilled if they tried to ban the conference.

Security has been high around Kairouan since Saturday, with police checking IDs and searching the cars of anyone entering the city.

Residents appeared to welcome the security and handed out roses to patrolling police, offering their encouragement.

Since the overthrow of Ben Ali in an uprising that heralded the region-wide Arab Spring, Tunisia's salafis have become increasingly aggressive about preaching their conservative version of Islam.

Last year's Ansar al-Shariah conference in Kairouan drew some 4,000 attendees and featured sword waving horse riders and martial arts displays, along with a great deal of fiery rhetoric.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-05-19-Tunisia-Salafis/id-881a3807fc1e405eb7724505f2bdfbe2

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Electric Daisy Carnival Kicks Off With Amped-Up Set From Steve Angello

New York's annual EDM fest gets off to an electrifying start as 40,000 fans pack Citi Field.
By Sarah Harper

Source: http://www.mtv.com/news/articles/1707611/electric-daisy-festival-2013-steve-angello.jhtml

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Cosmonewts Come Home After Russians Send Animals To Space

45 mice, 15 newts, eight gerbils and a handful of snails returned to Earth today after a month in space in a Russian capsule. The Bion-M completed a parachute-assisted landing about 750 miles southeast of Moscow, and researchers immediately set up a mobile lab near the capsule to begin tests on the animals.

According to the Associated Foreign Press, it was necessary for the critters to have their own capsule because they would have "posed a health risk" if they had been on the ISS.

The research is part of Russia's initiative to create a base on Mars beginning in 2030 that would facilitate manned missions. The animals will contribute to understanding of how the skeletal, nervous and muscular systems are affected by weightlessness during long flights. The AFP noted, somewhat menacingly, that:

Scientists said the animals were needed because they were subject to the kinds of experiments that are impossible to be conducted on humans.

Oooooh that kind of experiment. Okay, sure. Space party! It is also unclear whether all the animals survived the trip. But this has taken a dark turn. The point is that animals in space are cute and helpful, right? Guys? [PhysOrg]

Source: http://gizmodo.com/cosmonewts-come-home-after-russians-send-animals-to-spa-508696721

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The Last of Us will debut 'play while it downloads' feature on the PS3

The Last of Us

Even though we don't yet know what the PlayStation 4 looks like or how much it will cost, one of the many details revealed at Sony's February event was that games will be playable even as they download. Now it turns out we won't have to wait for the new hardware to experience that feature on a console -- Steam, for example, does this on PCs with some games -- as The Last of Us leaders Bruce Straley and Neil Druckman told Game Informer the PS3 game will be available as a download the same day it arrives on discs, and is playable once the transfer is 50 percent complete. There's no word whether other developers will have access to the "magic" Naughty Dog worked out with Sony to make it happen, but as least there will be as little delay as possible before you begin exploring its post-apocalyptic landscape June 14th.

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Comments

Via: Joystiq

Source: Game Informer

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/xWk-cKGbABU/

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Sunday, May 19, 2013

Internet Marketing Techniques And Tips For Everyone ? Nuhitz ...

Many businesses have turned to Internet marketing as their preferred marketing method. You can learn a lot by studying what those other guys are doing via marketing. With the right marketing tactics, in fact, you can become successful in any genre. Keep reading to find out how you can get more out of your Internet marketing with email.

Watch how your brand is discussed online, then use this type of language in your advertising copy. By speaking with them in terms they understand, you can better connect with them. When you use the right vernacular for your brand messaging it can connect better.

Don't delete stuff that hasn't yet worked. What did not work at one time, may well work in the future. People are still learning new things about the Internet so they just might not be ready for what you have to promote. Don't sink extra time and money into ideas that aren't working, but hang onto them in case they become viable down the road.

You can do Internet marketing in several ways; one of the easiest ways is to put ads on the Internet. You can achieve this by using Google's AdSense. For your effort and the reasonable cost, this is one of the best bargains around.

It seems impressive when people see that you have profiles on Facebook, MySpace, Twitter and a bunch of other social networking sites, but you need to keep adding information to make your profiles stay fresh. When profiles are not updated regularly, people start to view them as being spam.

To advertise your product, you should create a sort of FAQ. Be truthful in your questions and answers, but portray your business in the best possible light. Just be sure to avoid making it look like an advertisement by going overboard with product suggestions.

Many people are skeptical of information they read in advertising. Like Pavlov's dogs, people have been trained to be suspicious of an advertiser's honesty. Don't mislead people in any way about your services or products on your website. Try using before/after pictures, testimonials and reviews. Don't claim that your product or service does something you're not able to prove. You should be respectful of your customers and provide them with quality content. Always be polite and develop good relations with your customers. You will get a great reputation and gain customers to do business with for a long time.

Know how to code HTML tags. HTML tags serve to indicate how important various content is within your website. Search engine spiders use tags to determine the purpose and relevance of your site. You need to be sure to put extra emphasis on the keywords that are very important to your business.

Use high resolution images to showcase your products on your website. A clear and crisp graphic of your product will be appreciated by your customers. Include a "customer image" section on your website. Before and after shots can be an effective selling tactic.

Try not to give up. When you feel discouraged, remind yourself that success may be just around the corner. Have everything prepared before you start selling. Oftentimes, Internet marketing requires consistent and painstaking work. Keep your focus on your end result and realize that your hard work will pay off.

Are you searching for some way to do online marketing? If your customers have a viable reason to give their email, they will. This in turn will grow your email list. Organize contests and give away free products to keep people interested. It is much easier to get people's email addresses if you offer them a chance at a tempting prize.

Offering visitors to your website something that they can't get elsewhere encourages more visits to your site. Offer quality information such as articles, videos, pictures, podcasts, games and anything else your audience might be interested in. If you have a niche that no one else does, you will have great success.

Direct marketing should not be overlooked as a complement to the marketing system for your Internet site. Contact customers by fax, phone, or email and tell them about your specials and services. A lot of the needed information can be acquired by consulting the actual yellow pages or the phone books available online.

Consider what customers might have in mind when they seek out your site. If you can cater to their expectations for your site, you will notice a sharp upturn in sales and duration of site visits. Also do not be afraid to solicit objective opinions from customers. You might also consider soliciting feedback from friends, family members or online forums. Take notes and try to make the necessary changes to your site and strategy.

The tips in this article outlined some different techniques that may help you with your business. Once you understand these tips, start applying them to your business. This experimentation could point you towards important improvements you can make to your business strategy. What is important is that you continue learning and be fearless about trying new schemes.

For more on just click the following document have a look at http://www.completeseopackage.net

Source: http://www.nuhitz.com/blog/39649/internet-marketing-techniques-and-tips-for-everyone/

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Dennis Rodman to Kim Jong-un: 'Do me a solid' and free Kenneth Bae (+video)

US basketball star Dennis Rodman recently hung out with North Korea's leader Kim Jong-un - now he's tweeted a request?that the American sentenced to 15 years' hard labor be released.

By Ryan Lenora Brown,?Correspondent / May 9, 2013

North Korean leader Kim Jong-un (l.) and former NBA star Dennis Rodman watch North Korean and US players in an exhibition basketball game at an arena in Pyongyang, North Korea, in February. Rodman is tapping his friendship with Kim Jong-un when he tweeted a request 'to do me a solid' and free Kenneth Bae, a Korean-American man detained in the North.

Jason Mojica/VICE Media/AP/File

Enlarge

When Dennis Rodman spent a week touring North Korea in February, he had nothing but glowing words for the country?s leader, Kim Jong-un.

Skip to next paragraph Ryan Lenora Brown

Correspondent

Ryan Brown edits the Africa Monitor blog and contributes to the national and international news desks of the Monitor. She is a former Fulbright fellow to South Africa and holds a degree in history from Duke University.?

Recent posts

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?Guess what? I love him,? he told reporters. ?He?s really awesome.?

But now the basketball diplomat is testing his friendship with the young Kim by asking the leader to release an American sentenced last week to 15 years of hard labor for ?hostile acts? against the North Korean regime.

?I?m calling on the Supreme Leader of North Korea, or as I call him, ?Kim,? to do me a solid and cut Kenneth Bae loose,? Mr. Rodman tweeted Tuesday.?

The missive came in response to a Seattle Times opinion piece last week, in which writer Thanh Tan called on Rodman to put his goodwill with Pyongyang on the line for Mr. Bae, a tour operator arrested in November on murky charges.

Perhaps now is the time for the NBA has-been to practice some real basketball diplomacy and call up his so-called friend for a favor: Grant American detainee Kenneth Bae amnesty and release him to his family?.

Bae is being used as a political pawn by a desperate despot who happened to?gallivant around the country with Rodman?in March. Perhaps now is the retired player?s chance to use his notoriety for something other than to over-inflate his ego.

Rodman apparently got the message.

?In direct response to your article headline, 'Ok.' Read your story @uscthanhtan, and I decided to help,? he tweeted.

And while Twitter is an admittedly feeble platform for diplomacy, it?s not out of the question that Kim will see the tweet. After all, the North Korean government has an active ? if bizarre ? Twitter presence itself, putting out an erratic blast of messages about American imperialism and the ?victory and glory? of the Kim regime.

But even if Kim gets Rodman?s message, will he understand it? After all, ?do me a solid? isn?t exactly a phrase that translates easily.

Washington Post blogger Max Fisher writes that the closest Korean equivalent of the colloquialism would be the somewhat menacing (at least to American ears) phrase, ?Look at my face and release Kenneth Bae.?

?Look at my face,? he writes, ?is a Korean expression that?s like a special, for-friends-only version of ?do me a favor.??

Whether Kim will look at Rodman?s face ? double nose ring and all ? remains to be seen, but Americans favored by North Korea have helped coax the regime to release American prisoners in the past.

In 2009, for instance, former President Bill Clinton visited Pyongyang and shortly after the visit then-Dear Leader Kim Jong-il pardoned two American journalists who were being held in the country. In total, six Americans ? including Bae ? have been held by the North Korean government since 2009, the Monitor reported. The other five were all released.

Rodman?s February visit to North Korea ? along with the friendship tour of Google Chairman Eric Schmidt in January ? was initially hailed by some Western observers as a sign that the young Kim might be more interested in opening his country to the rest of the world than his father and grandfather had been.

However, analysts say there have been no fundamental changes to the regime?s posture since then. If anything, interaction with Western celebrities puts the regime in a more powerful position because it can claim new geopolitical cache.?

?Ultimately, they [North Korea] come out ahead because they can portray it as the world coming to pay tribute, or at least to be there,? Aidan Foster-Carter, a Korean expert, told the Monitor in March.

Indeed, as the state-run Korean Central News Agency (as well as Western outlets) reported during Rodman?s trip, the basketball player was an enthusiastic tourist, visiting a greatest hits list of Kim-related sites.?

Rodman and his cohort "paid high tribute to Kim Il Sung and Kim Jong Il before their statues. They entered the halls where Kim Il Sung and Kim Jong Il lie in state and paid homage to them,? a press release announced. ?They made an entry in the visitor's book.?

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/231i8YePVWE/Dennis-Rodman-to-Kim-Jong-un-Do-me-a-solid-and-free-Kenneth-Bae-video

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Good Tips On How To Make Sure You're Homeschooling Right ...


Tip! Textbooks are not the only way to learn. Kids should be welcome to read anything, from a blog to CNN.

Private schooling is not have to spend a fortune for your child to get a good education. Homeschooling is a good way to give your child the costs associated with private education. This article will get you out.

Tip! Learning happens all around us whether in the classroom or at the park. Children can learn from everything you do through out the day.

Check your State?s mandates before you set up your curriculum. Many states regulate how homeschooling must be done within the area you live. It usually a good idea to keep your lesson plans in sync with the local district?s.

Tip! Find other home school families in your area and do field trips together. This simultaneously provides hours of fun and socialization time.

Don?t limit your children only to the required books in a subject. Your kid should learn using a variety of materials like newspapers and comic books. Discussing current events is a great way to teach your child about everything from our political system to geography. It can also teach them all through life.

Tip! You might not want your children to spend time with ruffians from the public school, they will need some social interaction with kids their age. Plan to get together with family and friends for playdates.

Go on excursions with other families who are homeschooling families. This simultaneously provides hours of fun and it will allow your kids to be social with other children. You might also get group discounts at some places.

Tip! Compared with the traditional classroom setting, homeschooling offers greater opportunities to accommodate your child?s unique learning style. If your kid is better with hands-on teaching, you can have lots of hands-on lessons.

One benefit of homeschooling is that you can create lessons that mesh with your lessons to your child?s strengths. This kind of structuring helps your child to be more successful learning.

Tip! Get in touch with the homeschooling association in your state to find out the rules where you live. Depending on your state, you may have to register your homeschool as a privately owned school, or make sure your kids can pass standardized tests.

Set up an area for your preschoolers with their favorite toys and crafts they can use while you are teaching older kids. The older kids can assist the younger siblings. This lets everyone learn and will instill confidence.

Make sure you do as much research before jumping into homeschooling. There is an abundance of homeschooling resources online and your family.

Tip! Are you homeschooling multiple kids? You need to know if your discipline style will work. Without clear cut rules, it will be very hard to keep everyone from acting out, and this can lead to a less productive classroom experience.

Write down a list of the pros and cons of both public school and homeschooling. Use the list to make sure your lessons to include those things you thought they were missing out on in public school. It can be a helpful checklist to help you know what to avoid and what to do. Keep it somewhere where it can?t get lost and make sure that you can use it as a reference.

Tip! Find out all you can about the various styles of learning. You can turn your lesson plans into a targeted study for your child.

Reach out to other homeschoolers like you. There are many different factors that families homeschool their children. You can probably find or create a group of others with similar to yours. Homeschooling groups are also a great place to get advice and support if you?re new to it.

Tip! When your child is struggling with the public school system, you may want to consider homeschooling. This will put less pressure on your child during their learning process.

Now that you?re more informed about homeschooling, you should be aware of whether or not you can do it. You just need the right knowledge and passion for getting started. If you implement the information that was shared with you in this article, you will be headed down the right path to becoming an outstanding teacher for your children.

Source: http://talkonmovie.com/good-tips-on-how-to-make-sure-youre-homeschooling-right/

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New smartphone application improves colonoscopy preparation

New smartphone application improves colonoscopy preparation [ Back to EurekAlert! ] Public release date: 18-May-2013
[ | E-mail | Share Share ]

Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
Digestive Disease Week

Innovation for healthy outcomes presented at DDW 2013

Orlando, FL (May 18, 2013) The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in advance of the procedure, includes dietary restrictions and requires specific bowel preparation medication to be taken at strict intervals. The better the preparation, the easier it is for doctors to see cancer and precancerous polyps in the colon. The study, which was conducted by the gastroenterologists of Arizona Digestive Health in Phoenix, featured the first doctor-designed app of its kind.

"Getting ready for a colonoscopy is difficult. There are a lot of steps," said Nilay Kavathia, MD, a gastroenterology fellow at Phoenix VA, who is one of the application's developers. "For patients, having an interactive, simplified and personalized app on their phone is like having a doctor at their side throughout the process."

In the study comparing the quality of bowel preparation by patients who used the app and those who did not, Dr. Kavathia found that 84 percent of individuals who used the app received a good score on the nine-point Boston Bowel Preparation Scale. By contrast, only 56 percent of those who didn't use the app received a good score. The results, which correspond with health technology trends, show how advances in smartphones are helping physicians achieve better patient outcomes.

To help increase quality bowel preparation, Dr. Kavathia worked with Dr. Paul Berggreen, the president of Arizona Digestive Health, to develop the "Arizona Digestive Health" app. Patients enter the date and time of the procedure and the bowel preparation medication chosen by their physician. Timed alerts then appear on the phone to remind the individual of the next step in bowel preparation. In addition to the alerts, the app offers information explaining the procedure, tips and pictures of preparation quality. It is available for free download.

Dr. Kavathia would like to build upon his findings by studying individual outcomes of patients who use an app to get ready for a colonoscopy. "We know that better prep means a better colonoscopy," he said, "and now we know that this app improves prep. This finding has huge implications for treatment, patient satisfaction and further research in how the use of technology can impact healthy outcomes."

A colonoscopy serves as a screening test for colorectal cancer and allows a doctor to look for polyps, or precancerous growths, in the colon and rectum. When men and women are considered together, colorectal cancer is the second leading cause of cancer-related deaths in the U.S. and the third most common cancer for both sexes. Colonoscopies for average risk patients are recommended beginning at age 50.

The success of a colonoscopy depends greatly on the quality of bowel preparation by the patient. Inadequate preparation can force cancellation of an exam or can result in a compromised exam in which polyps go undetected, an increase in procedure time and more frequent surveillance.

###

Dr. Kavathia will present data from the study "Outcomes of smart phone application assisted bowel preparation for colonoscopy," abstract 143c, on Saturday, May 18, at 2:30 p.m. ET in Room 203AB of the Orange County Convention Center.

Digestive Disease Week (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 18 to 21, 2013, at the Orange County Convention Center, Orlando, FL. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at http://www.ddw.org.

Follow us on Twitter @DDWMeeting; hashtag #DDW13. Become a fan of DDW on Facebook


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New smartphone application improves colonoscopy preparation [ Back to EurekAlert! ] Public release date: 18-May-2013
[ | E-mail | Share Share ]

Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
Digestive Disease Week

Innovation for healthy outcomes presented at DDW 2013

Orlando, FL (May 18, 2013) The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in advance of the procedure, includes dietary restrictions and requires specific bowel preparation medication to be taken at strict intervals. The better the preparation, the easier it is for doctors to see cancer and precancerous polyps in the colon. The study, which was conducted by the gastroenterologists of Arizona Digestive Health in Phoenix, featured the first doctor-designed app of its kind.

"Getting ready for a colonoscopy is difficult. There are a lot of steps," said Nilay Kavathia, MD, a gastroenterology fellow at Phoenix VA, who is one of the application's developers. "For patients, having an interactive, simplified and personalized app on their phone is like having a doctor at their side throughout the process."

In the study comparing the quality of bowel preparation by patients who used the app and those who did not, Dr. Kavathia found that 84 percent of individuals who used the app received a good score on the nine-point Boston Bowel Preparation Scale. By contrast, only 56 percent of those who didn't use the app received a good score. The results, which correspond with health technology trends, show how advances in smartphones are helping physicians achieve better patient outcomes.

To help increase quality bowel preparation, Dr. Kavathia worked with Dr. Paul Berggreen, the president of Arizona Digestive Health, to develop the "Arizona Digestive Health" app. Patients enter the date and time of the procedure and the bowel preparation medication chosen by their physician. Timed alerts then appear on the phone to remind the individual of the next step in bowel preparation. In addition to the alerts, the app offers information explaining the procedure, tips and pictures of preparation quality. It is available for free download.

Dr. Kavathia would like to build upon his findings by studying individual outcomes of patients who use an app to get ready for a colonoscopy. "We know that better prep means a better colonoscopy," he said, "and now we know that this app improves prep. This finding has huge implications for treatment, patient satisfaction and further research in how the use of technology can impact healthy outcomes."

A colonoscopy serves as a screening test for colorectal cancer and allows a doctor to look for polyps, or precancerous growths, in the colon and rectum. When men and women are considered together, colorectal cancer is the second leading cause of cancer-related deaths in the U.S. and the third most common cancer for both sexes. Colonoscopies for average risk patients are recommended beginning at age 50.

The success of a colonoscopy depends greatly on the quality of bowel preparation by the patient. Inadequate preparation can force cancellation of an exam or can result in a compromised exam in which polyps go undetected, an increase in procedure time and more frequent surveillance.

###

Dr. Kavathia will present data from the study "Outcomes of smart phone application assisted bowel preparation for colonoscopy," abstract 143c, on Saturday, May 18, at 2:30 p.m. ET in Room 203AB of the Orange County Convention Center.

Digestive Disease Week (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 18 to 21, 2013, at the Orange County Convention Center, Orlando, FL. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at http://www.ddw.org.

Follow us on Twitter @DDWMeeting; hashtag #DDW13. Become a fan of DDW on Facebook


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/ddw-nsa051513.php

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