Saturday, April 27, 2013

Chorus grows against Obama administration's sanctions-heavy Iran policy

The Obama administration's effort to end Iran's nuclear program has focused on punitive measures, with little diplomatic outreach. Critics say this jeopardizes negotiations.

By Scott Peterson,?Staff writer / April 25, 2013

President Barack Obama leaves after speaking in the Brady Press Briefing at the White House in Washington, Friday, April 19, 2013.

Manuel Balce Ceneta/AP

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America?s nuclear negotiators with Iran?got it all wrong, according to a growing chorus of critics arguing that over-reliance on pressure and sanctions may be jeopardizing a diplomatic deal.?

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The Obama administration has?implemented?a host of crippling sanctions on Iran?targeting its?central bank and lifeblood oil exports.?The goal has been to pressure Iran?into giving?up its most sensitive nuclear work, which could be a pathway to an atomic bomb.

But a year of high-profile talks between Iran and world powers has yielded little progress. Now a number of senior former US officials and analysts say a White House obsession with the pressure track may be backfiring, and are calling for a?pivot toward?the diplomatic track?to?reestablish?balance.?

?I was in the [State] Department when they kept talking about the so-called two-track policy, and it was clear the whole thing was nonsense, there never were two tracks,? says John Limbert, the former US deputy assistant secretary of state for Iran?from 2009?to 2010.

?The sanctions took all the air out of the room. It was 95 percent sanctions, and that was on a good day.?

The US 'knows' sanctions

One reason for the sanctions focus is ?we know how to do them. It?s familiar. And to do them, we don?t have to deal with the Iranians; we deal with the British, the?United Nations, the Russians, the Chinese,? says Ambassador Limbert,?who was also?held captive?in Iran during the 1979 to 1981 hostage crisis,?and speaks fluent Persian.

?Whereas diplomacy with Iran, that?s hard. Nobody knows how to do that, and every time we?ve tried, we?ve failed, and as soon as we fail we?ve given up and gone back to doing what we know how to do.?

Limbert,?who?now teaches at the US Naval Academy,?is among a growing number of people calling for a recalibration of the American strategy on Iran ? a greater emphasis on diplomacy and real incentives, like substantial sanctions relief ? in exchange for real concessions by Iran.

?It is time for the administration to make the sweat equity investment in negotiations equal to what it has done on sanctions and the potential to use military force,? Tom Pickering, the former US Under-Secretary of State for Political Affairs, said at the launch?last week in Washington?of?a report by The Iran Project,?an independent group of former officials and professionals that seeks to improve official US-Iran ties.?

?First and foremost we believe the President needs to make that decision ???I want a deal? ? and instruct his people to get a deal," he said.?

Ambassador Pickering and Limbert were among 35 signatories of the report, which included other veteran diplomats and officials like Zbigniew Brzezinski, President Jimmy Carter's national security advisor; Ryan Crocker,?former ambassador to Afghanistan, Iraq and other trouble spots;?Lee Hamilton, a former congressman and vice chairman of the 9-11 Commission; and former Central Intelligence Agency chief Michael Hayden.

There are signs that message is getting through. Despite a strong desire on Capitol Hill and in Israel for more sanctions against Iran, Secretary of State John Kerry asked Congress last Thursday to hold off: ?We don?t need to spin this up at this point in time?. You need to leave us the window to try to work the diplomatic channel,? he said.

Fewer options

The widening bid for better diplomacy?comes?after the latest round of nuclear talks in the Kazakh city of Almaty earlier this month?failed to narrow differences?between Iran and the P5+1 group (the US, Russia, China, Britain, France and Germany).

Calling for ?strengthening the diplomatic track in order to seize the opportunity created by the pressure track,? The Iran Project notes that while US policies ?possibly slowed the expansion of Iran?s nuclear program,? they also ?may have narrowed the options for dealing with Iran by hardening the regime?s resistance to pressure.?

The report states that ?it seems doubtful that pressure alone will change the decisions of Iran?s leaders,? though stronger diplomacy ?that includes the promise of sanctions relief in exchange for verifiable cooperation? could lead to a deal. Another risk of current policy, warns the report: ?Sanctions-related hardships may be sowing the seeds of long-term alienation between the Iranian people and the United States.?

The current P5+1 offer,?which has been seen by The Christian Science Monitor, calls upon Iran to halt enrichment of uranium to 20 percent purity ??which is a few technical steps away from bomb-grade of more than 90 percent ? and ?reduce readiness? of a deeply buried enrichment facility by disconnecting and removing key equipment.

After those steps, the P5+1 would provide partial sanctions relief on gold transfers and petrochemical exports, but not on far more painful financial or oil sanctions. Iran says the offer is unbalanced, and wants a more ?reciprocal? approach.

Supreme Leader Ayatollah Ali Khamenei stated in February that pressure and sanctions?are akin to the US ?pointing a gun at Iran?and?say[ing]?either negotiate or we will shoot.? In March, Khamenei said, ?if the Americans sincerely want? to resolve the nuclear issue ?they should stop being hostile towards the Iranian nation in words and in action.?

Both sides in the nuclear negotiations have staked out positions unacceptable to the other. Iran has signaled repeatedly in the past two years a willingness to cap its 20 percent enrichment, but has balked at the low price on offer.

?I think the answer is probably pretty simple. We?re going to have to sweeten the offer on sanctions relief,? former US assistant secretary of state?under the George W. Bush administration?and veteran troubleshooter James Dobbins said at the report launch. Sanctions should be suspended, not dropped,?he said,?until Iran also demonstrates it can hold to its side of any bargain.

?Is the level of mistrust so high, that it doesn?t matter at the end of the day what we offer?? asks Limbert. ?Anything short of a full surrender ? and maybe even that ? the Iranians are going to say, ?Well, obviously this is some trick?we?re not sure how you?re doing it, but we know you are.??

The same applies to US suspicions of Iran, adds Limbert: ?That?s exactly the way the two sides operate. This nuclear issue has gotten so invested with manhood [that] neither side feels it can back down.?

Has Obama already failed?

The Iran Project report is?only?the latest critique of White House handling of Iran that raises questions about missed opportunities and even the desire to make a deal.

The Atlantic Council earlier this month called for the US to prepare a roadmap that clarifies a ?step-by-step reciprocal and proportionate plan? to lift sanctions as Iran?s makes its own moves. ?To make meaningful concessions, Iran needs to see off-ramps and an endgame,??the Washington think tank concluded.?

Likewise, the Carnegie Endowment for International Peace and Federation of American Scientists this month determined: ?Washington?s overwhelming focus on coercion and military threats?has backed US policymakers into a rhetorical corner.??

Yet a further report, published by the International Crisis Group in February, noted how Iran and the West ?view the sanctions through very dissimilar prisms.? While the US and Europe count on a ?cost-benefit analysis? such that Iran will eventually cave in to hardship, ?the world looks very different from Tehran [where] the one thing considered more perilous than suffering from sanctions is surrendering to them.?

That disconnect has bedeviled the Obama White House, writes former administration official Vali Nasr in a book published this month, ?The Dispensable Nation.?

?The dual-track policy only gave Iran a reason to dig in deeper and clutch its nuclear ambitions tighter,? writes Mr. Nasr, who is now dean of the School of Advanced International Studies at Johns Hopkins University.

?In the end, Obama?s Iran policy failed. He pushed ahead with sanctions for the same reason Lyndon Johnson kept up the bombing of North Vietnam ? neither could think of anything else to?do," asserts Nasr. "Obama?s?sanctions-heavy approach did not change Iranian behavior; instead it encouraged Iran to accelerate its race to nuclear capability.??

Creating a solution may require a change in approach, say the authors of The Iran Project report.

?We have to do something the Iranians aren?t expecting, that gets them to stop and say, ?Wait a minute? maybe the Americans are serious,?? said James Walsh, a non-proliferation expert at the Massachusetts Institute of Technology, at the report launch.

?The only way this hard stuff will get done is if the President of the United States makes it his issue,? added Walsh. ?Absent that, we?re going to continue to do what we?ve done over and over again, only it will get worse.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/inI2WMQhPzY/Chorus-grows-against-Obama-administration-s-sanctions-heavy-Iran-policy

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Friday, April 26, 2013

Wednesday, April 10, 2013

Key pathway to stop dangerous, out-of-control inflammation discovered

Key pathway to stop dangerous, out-of-control inflammation discovered [ Back to EurekAlert! ] Public release date: 9-Apr-2013
[ | E-mail | Share Share ]

Contact: Kathleen Poe Ross
404-413-1374
Georgia State University

ATLANTA A potential new strategy to developing new drugs to control inflammation without serious side effects has been found by Georgia State University researchers and international colleagues.

Jian-Dong Li, director of Georgia State's Center for Inflammation, Immunity and Infection, and his team discovered that blocking a certain pathway involved in the biological process of inflammation will suppress it.

Inhibiting a molecule called phosphodiesterase 4B, or PDE4B, suppresses inflammation by affecting a key gene called CLYD, a gene that serves as a brake on inflammation.

The research was published in the journal Nature Communications.

Li explained the process of overactive inflammation using a "police" analogy.

When a pathogen such as bacteria or viruses -- infects a patient, he said, it triggers an "alarm" to which the "police" of immune system respond. In turn, it triggers neutrophil attractant called cytokines to respond, leading to inflammation that serves to help rid the body of the pathogen. But if inflammation isn't stopped, tissue damage can result.

The pathways during the response are termed "positive," like a gas pedal on a car, and "negative," like a brake, with the process in the positive pathway going down the line from the pathogen to inflammation, and negative going the other direction. PDE4B is involved in controlling the negative pathway.

Many researchers have been focusing on developing anti-inflammatory agents by stopping the positive pathway, but the discovery by Li and his colleagues gives scientists a new route to stop inflammation using safer or even existing drugs proven to be non-toxic as they have found that accelerating the negative pathway will reduce inflammation.

"This is the key negative regulator that we have been searching after for years, " Li said.

There is a need for better drugs to control inflammation, because current treatments come with serious side effects, Li said. Steroids are commonly used, but cannot be used over the long-term. Steroids suppress the immune system.

###

The research team included Kensei Komatsu, Ji-Yun Lee, Masanori Miyata, Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Haidong Xu, Chen Yan, Hirofumi Kai and Jian-Dong Li.

It was supported by grants from the National Institutes of Health, grant numbers DC005843 and DC 004562. Abstracts are available at http://projectreporter.nih.gov.

The article is "Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CLYD," in Nature Communications, available at http://hx.doi.org/10.1038/ncomms6274 or from Public Relations and Marketing Communications at 404-413-1374 or kpoeross@gsu.edu.

For more about Georgia State's Center for Inflammation, Immunity and Infection, visit http://inflammation.gsu.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Key pathway to stop dangerous, out-of-control inflammation discovered [ Back to EurekAlert! ] Public release date: 9-Apr-2013
[ | E-mail | Share Share ]

Contact: Kathleen Poe Ross
404-413-1374
Georgia State University

ATLANTA A potential new strategy to developing new drugs to control inflammation without serious side effects has been found by Georgia State University researchers and international colleagues.

Jian-Dong Li, director of Georgia State's Center for Inflammation, Immunity and Infection, and his team discovered that blocking a certain pathway involved in the biological process of inflammation will suppress it.

Inhibiting a molecule called phosphodiesterase 4B, or PDE4B, suppresses inflammation by affecting a key gene called CLYD, a gene that serves as a brake on inflammation.

The research was published in the journal Nature Communications.

Li explained the process of overactive inflammation using a "police" analogy.

When a pathogen such as bacteria or viruses -- infects a patient, he said, it triggers an "alarm" to which the "police" of immune system respond. In turn, it triggers neutrophil attractant called cytokines to respond, leading to inflammation that serves to help rid the body of the pathogen. But if inflammation isn't stopped, tissue damage can result.

The pathways during the response are termed "positive," like a gas pedal on a car, and "negative," like a brake, with the process in the positive pathway going down the line from the pathogen to inflammation, and negative going the other direction. PDE4B is involved in controlling the negative pathway.

Many researchers have been focusing on developing anti-inflammatory agents by stopping the positive pathway, but the discovery by Li and his colleagues gives scientists a new route to stop inflammation using safer or even existing drugs proven to be non-toxic as they have found that accelerating the negative pathway will reduce inflammation.

"This is the key negative regulator that we have been searching after for years, " Li said.

There is a need for better drugs to control inflammation, because current treatments come with serious side effects, Li said. Steroids are commonly used, but cannot be used over the long-term. Steroids suppress the immune system.

###

The research team included Kensei Komatsu, Ji-Yun Lee, Masanori Miyata, Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Haidong Xu, Chen Yan, Hirofumi Kai and Jian-Dong Li.

It was supported by grants from the National Institutes of Health, grant numbers DC005843 and DC 004562. Abstracts are available at http://projectreporter.nih.gov.

The article is "Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CLYD," in Nature Communications, available at http://hx.doi.org/10.1038/ncomms6274 or from Public Relations and Marketing Communications at 404-413-1374 or kpoeross@gsu.edu.

For more about Georgia State's Center for Inflammation, Immunity and Infection, visit http://inflammation.gsu.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/gsu-kpt040913.php

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'Pain & Gain' Pumps Up Sneak Peek Week: Tune In Tonight!

Mark Wahlberg and Michael Bay will present an exclusive clip from the action comedy, only on MTV at 11 p.m. ET.
By Brett White


Mark Wahlberg in "Pain and Gain"
Photo: Paramount Pictures

Source: http://www.mtv.com/news/articles/1705218/pain-gain-mark-wahlberg-sneak-peek-week.jhtml

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Burglars steal Vudu account IDs, passwords - Technology on ...

Streaming video provider Vudu announced that a break-in March 24 resulted in the theft of hard drives containing customer information, including names, email addresses, postal addresses, phone numbers, account activity, dates of birth and the last four digits of some credit card numbers.

According to Vudu, full credit card numbers were not stolen and that user passwords were encrypted. However, Vudu provided no details on the type of encryption used and whether it could be easily broken.

A statement from Vudu was not encouraging, "We believe it would be difficult to break the password encryption, but we can't rule out that possibility given the circumstances of this theft."

Therefore, all Vudu users should immediately change their passwords on any other sites on that use the same password as your Vudu account. Also, because emails addresses and other personal information were stolen, Vudu customers should be extremely cautious of phishing emails requesting passwords or other personal or financial information.

To help assist with future problems related to the data theft, Vudu ? which was bought by Walmart in 2010 ? has arranged for all customers to receive one year of identity protection services from AllClearID. Enrollment is not required. AllClear services can be accessed, if needed, from your Account Information page on the Vudu site.

More from Techlicious:

Source: http://www.nbcnews.com/technology/technolog/burglars-steal-vudu-account-ids-passwords-1C9286083

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Microsoft's Latest ?Scroogled? Ads Attack Sharing Of Information That Google Developers Need To Process Transactions

Screenshot_4_9_13_1_48_PMToday, Microsoft has leveled more accusations about Google’s practices by way of its “Scroogled” campaigns. This time, the complaints are about how Google handles users’ data when they purchase an application from Google Play. Previous “Scroogled” campaigns have targeted both Gmail and search over ads and privacy. In the two videos below, Microsoft uses animations and words to walk you through “what might happen” if your data were to end up in the wrong people’s hands. It’s a fear campaign, and it really doesn’t have any basis whatsoever. Take a look at the videos and we’ll get into what actually happens when you buy an app from Google Play. In the second video, a “real life” situation is played out on the front steps of an apartment building: A Google spokesperson provided us with the following statement: Google Wallet shares the information needed to process transactions and maintain accounts, and this is clearly stated in the Google Wallet Privacy Notice. Why the mention of Google Wallet? The main difference between Google Play and the Apple App Store is that Google uses its “Wallet” service to process transactions. While it’s not a third-party service in the sense that it’s a different company, it is a function of the process that is not embedded into the Google Play experience. It’s something that users are made aware of in the terms of service and privacy policies when they sign up. More importantly, when merchants and developers sign up to sell things in Google Play, they must buy into not sharing any of the information that they get, which is name, email address and general location — the things that all companies selling things online need in order to process your transaction and provide support. Better start your attack against Amazon, Etsy and everyone else on the Internet, Microsoft. The timing is interesting on this, because this is the way that Google Play has always worked. Its privacy policies haven’t changed since last July, in fact. At the end of the video, if you got that far, you’ll notice that Microsoft ends things with a big “Windows Phone doesn’t do it this way.” Instead of doing an advertisement on how great Windows phones and apps are, Microsoft has decided to go after how “horrible” Google is. The “Scroogled” site even has a big old link to explore Windows Phones. Isn’t that convenient? If Microsoft

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4O-3FJZyxpo/

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Nervy flyers be warned: warming will boost turbulence

Brace yourself: global warming is going to be a bumpy ride ? literally. The amount of moderate to extreme turbulence affecting transatlantic flights could more than double by the middle of the century as carbon dioxide levels increase.

Turbulence can develop where clouds and storms create updraughts and downdraughts. More problematic for planes, though, is clear-air turbulence. This occurs where air at one altitude is travelling faster than the air immediately below, leading to atmospheric instabilities.

"Clear-air turbulence is invisible to the human eye and also to the electronics on planes, which makes it difficult to avoid," says Paul Williams at the University of Reading, UK. Current estimates suggest that, on average, around 1 per cent of a transatlantic flight is spent flying through moderate to extreme clear-air turbulence.

Williams and Manoj Joshi at the University of East Anglia in Norwich, UK, used climate models to work out whether that 1 per cent figure is likely to rise as atmospheric carbon dioxide levels increase. The models show that the high-altitude atmospheric jet streams will accelerate as CO2 levels climb. This speeding up, relative to the air immediately below, will lead to more clear-air turbulence at exactly the cruising altitude of transatlantic flights.

Jet stream migration

What's more, the models also suggest that the jet streams will migrate slightly northwards. This will shift the patch of the most severe clear-air turbulence from the central Atlantic to the north Atlantic ? right into the path of many flights.

Williams and Joshi calculated that if CO2 levels double relative to pre-industrial levels ? an event projected to occur by the middle of the century if current emission trends continue ? the twin effects on the jet stream could lead to the strength of flight turbulence increasing by between 10 and 40 per cent, and an increase in the frequency of moderate to extreme turbulence of between 40 and 170 per cent.

With perhaps five minutes of a typical 8-hour flight today subject to such turbulence, a 170 per cent increase ? to around 13 1/2 minutes ? might seem trivial to anyone but those with an extreme fear of flying. "You could argue a few more drinks will get knocked over. So what?" says Williams. But he says that the extra turbulence could cost the aviation industry dear, by accelerating aircraft wear and tear, for instance.

Robert Sharman at the National Center for Atmospheric Research in Boulder, Colorado, researches flight turbulence. He says it is difficult to predict it even on a daily basis, and there is no single forecasting technique that researchers can agree to use. Williams and Joshi tackled this problem, he says, by using several of the most popular turbulence forecasting techniques ? and almost all suggested clear-air turbulence would rise.

Michael Sprenger at the Swiss Federal Institute of Technology in Zurich says future technologies should make it easier to identify and avoid clear-air turbulence, so any rise in the level of turbulence might have little impact on flights. However, if planes begin taking more convoluted routes to avoid turbulence, flight times and fuel consumption will rise, say Williams and Joshi, which may only aggravate the problem by adding yet more CO2 to the atmosphere.

Journal reference: Nature Climate Change, doi.org/k4m

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Source: http://feeds.newscientist.com/c/749/f/10897/s/2a780ebc/l/0L0Snewscientist0N0Carticle0Cdn233560Enervy0Eflyers0Ebe0Ewarned0Ewarming0Ewill0Eboost0Eturbulence0Bhtml0Dcmpid0FRSS0QNSNS0Q20A120EGLOBAL0Qonline0Enews/story01.htm

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Standard Chartered bulks up in S.Africa

JOHANNESBURG (Reuters) - Standard Chartered has opened two new branches in South Africa to target Cape Town and Durban-based companies looking to expand across the continent, its chief executive for Africa said on Tuesday.

The London-listed bank saw 28 percent growth in its South African business last year and is now looking to court local retailers, many of which are based in Cape Town, and trading housing operating in Durban, Diana Layfield told the Reuters Africa Investment Summit.

While Standard Chartered is dwarfed in South Africa by domestic powerhouses like Standard Bank and FirstRand, it is looking to use its presence in at least 15 African countries to win business from companies looking north.

"In South Africa, we have seen real opportunity recently," she said.

Standard Chartered is also scaling up its business in neighbouring Angola, where it recently inked a deal for a 60 percent stake in a joint venture bank with state-owned insurer ENSA.

Standard Chartered is investing a $100 million in Africa aimed at doubling the size of its business on the continent in the next five years. Its profit from Africa jumped 23 percent to $771 million in 2012.

Source: http://news.yahoo.com/standard-chartered-bulks-africa-115933184--finance.html

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